02502cam a22003858i 4500 18577358 PILC 20160524092044.0 150415s2016 nyu b 001 0 eng 2015014810 9780071830935 (hardcover : alk. paper) 0071830936 (hardcover : alk. paper) (DNLM)101656208 DNLM/DLC eng rda DLC pcc RM 301.4 .Sh531 2016 QV 38 615.7 Shargel, Leon, 1941- , author. Applied biopharmaceutics & pharmacokinetics / Leon Shargel, Andrew B.C. Yu. Applied biopharmaceutics and pharmacokinetics 7th edition. New York : McGraw Hill, 2016. 1511 xvii, 910 pages : illustrations ; 24 cm. Includes bibliographical references and index. Introduction to biopharmaceutics and pharmacokinetics -- Mathematic fundamentals in pharmacokinetics -- Biostatistics -- One compartment open model : IV bolus injection -- Multicompartmental models : IV bolus injection -- Intravenous infusion -- Drug elimination and clearance -- Pharmacokinetics of oral absorption -- Multiple dosage regimens -- Nonlinear pharmacokinetics -- Physiologic drug distribution and protein binding -- Renal and hepatic elimination of drugs -- Pharmacogenetics and drug metabolism -- Physiologic factors related to drug absorption -- Biopharmaceutic considerations in drug product design -- Drug product performance, in vivo : bioavailability and bioequivalence -- Biopharmaceutic aspects of the active pharmaceutical ingredient and pharmaceutical equivalence -- Impact of biopharmaceutics on drug product quality and clinical efficacy -- Modified release drug products and drug devices -- Targeted drug delivery systems and biotechnology products -- Relationship between pharmacokinetic and pharmacodynamics -- Application of pharmacokinetics in clinical situations -- Application of pharmacokinetics in specific populations -- Dosage adjustment in renal and hepatic disease -- Empirical models, mechanistic models, statistical moment and noncompartmental analysis. Biopharmaceutics. Pharmacokinetics. Drug Administration Routes. Models, Chemical. Yu, Andrew B. C., 1945- , author. 7 cbc orignew 1 ecip 20 y-gencatlg lcc BK 294929 294929 0 0 lcc 0 SSLC SSLC SSLC 2016-05-24 Library Fund 2 52 RM 301.4 .Sh531 2016 SSLC1440 2019-08-13 00:00:00 2019-07-11 2016-05-24 BK