Shargel, Leon 1941- creator author. Yu, Andrew B. C. 1945- author. text bibliography nyu New York McGraw Hill 2016 7th edition. monographic eng

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xvii, 910 pages : illustrations ; 24 cm. Introduction to biopharmaceutics and pharmacokinetics -- Mathematic fundamentals in pharmacokinetics -- Biostatistics -- One compartment open model : IV bolus injection -- Multicompartmental models : IV bolus injection -- Intravenous infusion -- Drug elimination and clearance -- Pharmacokinetics of oral absorption -- Multiple dosage regimens -- Nonlinear pharmacokinetics -- Physiologic drug distribution and protein binding -- Renal and hepatic elimination of drugs -- Pharmacogenetics and drug metabolism -- Physiologic factors related to drug absorption -- Biopharmaceutic considerations in drug product design -- Drug product performance, in vivo : bioavailability and bioequivalence -- Biopharmaceutic aspects of the active pharmaceutical ingredient and pharmaceutical equivalence -- Impact of biopharmaceutics on drug product quality and clinical efficacy -- Modified release drug products and drug devices -- Targeted drug delivery systems and biotechnology products -- Relationship between pharmacokinetic and pharmacodynamics -- Application of pharmacokinetics in clinical situations -- Application of pharmacokinetics in specific populations -- Dosage adjustment in renal and hepatic disease -- Empirical models, mechanistic models, statistical moment and noncompartmental analysis. Leon Shargel, Andrew B.C. Yu. Includes bibliographical references and index. Biopharmaceutics Pharmacokinetics Drug Administration Routes Models, Chemical RM 301.4 .Sh531 2016 615.7 QV 38 9780071830935 (hardcover : alk. paper) 0071830936 (hardcover : alk. paper) 2015014810 DNLM/DLC 150415 20160524092044.0 18577358 eng